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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac risk components using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, probably secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the proper coronary artery. Physicians and patients should be aware of the clinical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity.
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Patients also could also be taking concomitant stimulants, corresponding to ephedra, which may confound knowledge and the potential for adverse occasions. It is likely that the frequency of cardiac occasions is underreported in the medical literature. Moreover, testosterone has been used within the therapy of decreased muscle mass and bone density in addition to anemia. The position testosterone could play in the development of heart problems has more and more turn out to be the subject of present interest . Supraphysiologic doses of anabolic-androgenic steroids , which embody more than 30 natural and artificial derivatives of testosterone, may trigger a wide spectrum of scientific sequalae. Supplemental or physiologic doses of testosterone have noticed expanded use in medical practice recently. Other frequent potential antagonistic results embrace infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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However, testosterone in physiologic doses might even be helpful in patients with angina , have greater ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in males with established coronary artery illness . Therefore, an interaction of endogenous components of the patient’s risk profile in addition to the testosterone dosing could additionally be problems with whether or not antagonistic events occur. Erythrocytosis has been reported as a potential impact of testosterone, which may be useful in sufferers with anemia.
